Probability of Gene Fixation in an Expanding Finite Population
نویسندگان
چکیده
منابع مشابه
Probability of fixation of a mutant gene in a finite population when selective advantage decreases with time.
ROBABILITY of gene fixation, that is to say, the probability by which a muPtant allele becomes eventually established in a population is a subject of considerable interest both in population and evolutionary genetics. In his pioneering work, HALDANE (1927) showed that in an infinite population an individual mutant gene having selective advantage s can reach fixation with the probability of abou...
متن کاملThe fixation probability of rare mutators in finite asexual populations.
A mutator is an allele that increases the mutation rate throughout the genome by disrupting some aspect of DNA replication or repair. Mutators that increase the mutation rate by the order of 100-fold have been observed to spontaneously emerge and achieve high frequencies in natural populations and in long-term laboratory evolution experiments with Escherichia coli. In principle, the fixation of...
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A mutant gene which appeared in a finite population will eventually either be lost from the population or fixed (established) in it. The mean time until either of these alternative events takes place was studied by WATTERSON (1962) and EWENS (1963). They made use of a method previously announced by DARLING and SIEGERT (1953), and, independently by FELLER (1954). Actually, DARLING and SIEGERT re...
متن کاملRole of epistasis on the fixation probability of a non-mutator in an adapted asexual population.
The mutation rate of a well adapted population is prone to reduction so as to have a lower mutational load. We aim to understand the role of epistatic interactions between the fitness affecting mutations in this process. Using a multitype branching process, the fixation probability of a single non-mutator emerging in a large asexual mutator population is analytically calculated here. The mutato...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1974
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.71.9.3377